The north London derby is always a fiery affair and will have the added spice of a Champions League place at stake.
Arsenal can confirm their place in next season’s top club competition in Europe with a victory at White Hart Lane, but a win for Spurs will throw things wide open.
Getting back into the Champions League will be a big moment for the Gunners and manager Mikel Arteta.
The club have not ended in the top four since the 2015/16 season under Arsene Wenger, when they came second.
It has been a story of patience for Arteta and Arsenal after back-to-back eighth place finishes and things are starting to come together.
There is a spine of young talent in the side, with many yet to experience Champions League football at all in their career.
Five of the likely starting XI against Tottenham will not have featured in the Champions League before, with Rob Holding (1) and Martin Odegaard (2) still inexperienced.
Ben White, who is injured, and Gabriel Martinelli, who often rotates with Emile Smith Rowe, can be added to that list too of yet to make their debut in the competition.
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Arsenal players’ Champions League experience
Many of the players from the regular starting XI have yet to play top tier European football
Granit Xhaka – 22 games
Mohamed Elneny – 17
Kieran Tierney – 9
Gabriel – 6
Martin Odegaard – 2
Rob Holding – 1
Aaron Ramsdale – 0
Takehiro Tomiyasu – 0
Emile Smith Rowe – 0
Bukayo Saka – 0
Eddie Nketiah – 0
They will also likely lose a lot of Champions League experience over the summer too with Alexandre Lacazette (18) and Bernd Leno (37) likely to go, while Mohamed Elneny (17) only recently offered a new contract.
Martin Odegaard is keen to go from spectator to Champions League player.
“We’re watching all the games,” he said ahead of the game.
“When you watch those games you want to be there and fight for the best games, so that’s the stage we want to be at.
“[Qualifying for the Champions League] was our big goal this season, so if we can do it we’ll be very happy.
“Of course to do it there will be special, but the most important thing is to get there and not the way we do it.”
Their rivals Tottenham boast far more Champions League experience in their squad, four times as much in fact.
While the Gunners languished outside the top tier European competition, Spurs were making it all the way to the final and regularly finished in the top four of the Premier League.
They count a total of 222 Champions League appearances in their likely starting line-up, with Hugo Lloris leading the way on 56 – one shy of the whole Arsenal team combined.
But they are unlikely to add to that any time soon as all things point to the Gunners grabbing fourth spot and heading back to the Champions League.
Tottenham Champions League experience
Goalkeeper Lloris has almost played as many Champions League games than the whole of Arsenal’s starting XI
Hugo Lloris – 56 games
Heung-min Son – 45
Rodrigo Bentancur – 31
Harry Kane – 24
Eric Dier – 23
Ben Davies – 19
Dejan Kulusevski – 11
Cristian Romero – 7
Pierre-Emile Hojbjerg – 3
Ryan Sessegnon – 3
Emerson Royal – 0