Arsenal have been paired against PSV Eindhoven, and Manchester United will meet Real Sociedad in the Europa League group stage.
The draw, which took place in Istanbul on Friday, saw the two sole British representatives learn who stands in their way as two of the favourites for glory in the competition.
Mikel Arteta’s Gunners will be hoping to return to a final they last reached in 2019 under Unai Emery.
Meanwhile, Man United will be aiming for another long run in a competition that saw them lift their last trophy in 2017.
That final was won against Ajax, who named Erik ten Hag as their manager in the preceding months with the Dutchman now at Old Trafford.
Both English sides missed out on a place in the Champions League to Tottenham Hotspur in the final weeks of the 2021/22 Premier League season.
The winners of the Europa League gain a spot in Europe’s top tier competition, meaning Arsenal and United will likely be taking the tournament particularly seriously.
Arsenal will come up against some winning pedigree in the shape of the reigning Norwegian and Swiss champions, Bodo/Glimt and FC Zurich.
But the most intriguing team they will face – in Group A – is PSV.
They are now managed by Manchester United and Real Madrid legend Ruud van Nistelrooy, who famously had a number of heated run-ins with the Gunners.
LaLiga top four battlers Real Sociedad will present United with an interesting challenge in Group E, as will FC Sheriff, who last season beat Real Madrid in the Champions League group stages.
United will also be up against former Celtic manager Neil Lennon’s Omonia Nicosia.
Elsewhere, Jose Mourinho will be taking on former Premier League rival Manuel Pellegrini, with Roma drawn against Real Betis in Group C.
The full group stage draw is as follows:
Group A: Arsenal, PSV, Bodo/Glimt, FC Zurich
Group B: Dynamo Kyiv, Rennes, Fenerbahce, Larnaca
Group C: Roma, Ludogorets, Real Betis, Helsinki
Group D: Braga, Malmo, Union Berlin, Union Saint-Gilloise
Group E: Manchester United, Real Sociedad, FC Sheriff, Omonia Nicosia
Group F: Lazio, Feyenoord, Midtjylland, Sturm Graz
Group G: Olympiacos, Qarabag, Freiburg, Nantes
Group H: Crvena Zvezda, Monaco, Ferencvaros, Trabzonspor